Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease
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چکیده
منابع مشابه
IL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders
Background: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. Objective: The aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in Iranian population. Methods: One hundred and forty ...
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Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss of vision, pain, and high IOP. Even when medical and surgical treatment is avai...
متن کاملil-1β (+3953 c/t) and il-8 (-251 a/t) gene polymorphisms in h. pylori mediated gastric disorders
background: previous studies imply that il-1 and il-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon h. pylori infection. objective: the aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in iranian population. methods: one hundred and forty ...
متن کاملHyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
OBJECTIVE Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance. In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance. RESEARCH DESIGN AND METHODS ob/ob animal...
متن کاملOligomerized CARD16 promotes caspase-1 assembly and IL-1β processing
Increasing evidence indicates that caspase recruitment domain (CARD)-mediated caspase-1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)-1β release, leading to the initiation of inflammation. Both CARD16 and CARD17 were previously reported as inhibitory homologs of CASP1; however, their molecular function remains unclear. Here, we identified that oligo...
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ژورنال
عنوان ژورنال: Gut Microbes
سال: 2016
ISSN: 1949-0976,1949-0984
DOI: 10.1080/19490976.2016.1182289